Scientists have identified a gene that may play a major role in the aging process.
Researchers have discovered a gene, EDA2R, that plays a significant role in aging by driving chronic inflammation—a key factor in age-related diseases like heart disease, diabetes, and muscle weakness. The study, published in Nature Communications, analyzed genetic data and found that higher EDA2R activity correlates with increased inflammation markers in humans and accelerated aging in animals.
Led by Dr. Ildus Akhmetov of Liverpool John Moores University, the international team found that suppressing EDA2R in lab tests reduced harmful inflammation and improved muscle health. Blood tests from over 5,000 people confirmed the link between EDA2R and elevated C-reactive protein (CRP), a key inflammation indicator.
Promisingly, existing interventions—exercise, calorie restriction, ginkgo supplements, and metformin—may help lower EDA2R activity. The findings open new avenues for therapies targeting age-related decline.